Cancer trials

Trials open to recruitment

ATRiUM

Use of Gemcitabine as a sensitizer for ATR inhibition in the treatment of selected patients with pancreatic cancer. Using model based, dual agent clinical trial design, this trial should overcome the current “challenges” of combining cytotoxic…

CamBMT1 - Cambridge Brain Mets Trial

The CamBMT1 trial has been designed to try and improve the treatment of cancers that have spread to the brain (sometimes known as brain metastases, or secondary brain tumours). In the past it has been found that many anticancer drugs are unable…

CAMPAN-1

Information coming soon

INTERIM

Doctors use the combination of dabrafenib and trametinib to treat advanced melanoma that has the BRAFV600 gene change (mutation). Unfortunately melanoma can…

LUCID

Taking as reference tumour-specific somatic genetic alterations identified within individual cancer biopsies from patients, recent advances in genomic and next generation sequencing technologies now provide the opportunity to investigate whether…

MelResist

Information coming soon

Neo-RT

Four in 10 women diagnosed with breast cancer undergo mastectomy with or without breast reconstruction and less than half are satisfied with how they look unclothed. Breast conservation (removing the area with the lump only) can offer less…

PARTNER

Surgery is often used for early breast cancers however sometimes chemotherapy is given before surgery. This is called neoadjuvant chemotherapy, which can shrink the cancer and make surgery more successful. In this trial, researchers are looking…

PIONEER

Around 75% of breast cancers are defined and driven by Oestrogen receptor alpha (ERα) transcriptional activity. Standard treatment is endocrine therapy however clinical outcomes vary considerably, and a proportion of women with early breast…

PRaM-GBM

Brain tumours are the leading cause of cancer deaths in children, men under the age of 45 and women under the age of 25. Glioblastoma is the most common and most malignant primary tumour. The predominant treatment is surgical removal of the…

UK P3BEP

Germ cell tumours (GCTs) account for 98% of all testicular cancers. Germ cell tumours also arise in the ovary, accounting for 1% to 2% of ovarian neoplasms. Germ cell tumours also rarely arise in the mediastinum, retroperitoneum, ovary and brain…