Cancer trials

AZD6738 is a potent, selective inhibitor of the serine (Ser)/threonine (Thr)-specific protein kinase, ataxia telangiectasia and Rad3-related protein (ATR), with good selectivity against other phosphatidylinositol 3-kinase-related kinase (PIKK)…

Four in 10 women diagnosed with breast cancer undergo mastectomy with or without breast reconstruction and less than half are satisfied with how they look unclothed. Breast conservation (removing the area with the lump only) can offer less…

Metastatic pancreatic ductal adenocarcinoma (mPDA) is an aggressive form of cancer with very poor outcomes. It is generally treated with traditional chemotherapy but even…

Breast cancer is the most common cancer in women worldwide, and the second most common cancer overall, with more than 1,676,000 people newly diagnosed in 2012 (25% of all female cancer cases and 12% of the total). Although advances in screening,…

Brain tumours are the leading cause of cancer deaths in children, men under the age of 45 and women under the age of 25. Glioblastoma is the most common and most malignant primary tumour. The predominant treatment is surgical removal of the…

Treatment for melanoma patients is rapidly evolving, as new systemic therapies are improving outcomes in both the metastatic and adjuvant setting. Three key international randomised trials evaluating both immune checkpoint inhibitors and…

Study design
TAPS02 is a phase 3, randomised, multicentre, double-blind, placebo-controlled trial investigating the use of short-term androgen targeted therapy (sATT) in the form of apalutamide (Erleada) in men on active…

Germ cell tumours of the testis are the most common malignancy affecting adolescent and young adult males in Australia and many other Western countries, with a disproportionally high amount of healthy life lost each year due to the early age at…

Renal cell cancer (RCC) is the 7th commonest cancer in the UK (12,500 new cases/year) and the most lethal of the urological malignancies with a 50% 10-year survival when considering all patients. Vascular endothelial growth factor (VEGF) tyrosine…