Cancer trials

ARTemis

The first treatment for early breast cancer is often surgery. But having chemotherapy before surgery can help shrink the cancer. Shrinking the size of the cancer before surgery can mean you need a smaller operation.

Bevacizumab (Avastin)…

ATRiUM

Use of Gemcitabine as a sensitizer for ATR inhibition in the treatment of selected patients with pancreatic cancer. Using model based, dual agent clinical trial design, this trial should overcome the current “challenges” of combining cytotoxic…

AVAST-M

To compare overall survival of patients with resected melanoma at high risk of recurrence treated with bevacizumab compared with observation only.

CAM-PLEX

Pancreatic, ovarian and colorectal cancers are difficult to treat using chemotherapy and immune therapies.Currently most patients are offered treatment with a standard chemotherapy drug depending on their cancer type. Recently, laboratory studies…

CamBMT1 - Cambridge Brain Mets Trial

The CamBMT1 trial has been designed to try and improve the treatment of cancers that have spread to the brain (sometimes known as brain metastases, or secondary brain tumours). In the past it has been found that many anticancer drugs are unable…

CAMPAN-1

Information coming soon

CaNCaP02

Patients with localised prostate cancer can be treated by radical prostatectomy (prostate gland removal surgery) or radiotherapy. Around 15% of men with prostate cancer are diagnosed with high risk disease meaning they are more likely to suffer…

CaNCaP03

Despite recent advances in the treatment of Castrate-Resistant Prostate Cancer (CRPC), there remains an unmet medical need to identify and optimise additional treatment for those patients with early prostate cancer who are at greatest risk of…

EVIS

Pancreatic cancer is the fourth leading cause of cancer-related deaths in Western countries. It is a lethal disease that typically presents late, metastasises early and is resistant to conventional treatments such as radiation and chemotherapy.…

GALA-BIDD

Brain tumours (gliomas) are classified as low and high-grade. Correctly distinguishing high-grade glioma (HGG) from low-grade glioma (LGG) during surgery can influence the surgical procedure, enhancing resection and improving survival. The aim of…

INTERIM

Doctors use the combination of dabrafenib and trametinib to treat advanced melanoma that has the BRAFV600 gene change (mutation). Unfortunately melanoma can…

LUCID

Taking as reference tumour-specific somatic genetic alterations identified within individual cancer biopsies from patients, recent advances in genomic and next generation sequencing technologies now provide the opportunity to investigate whether…

MelResist

Information coming soon

Neo-RT

Four in 10 women diagnosed with breast cancer undergo mastectomy with or without breast reconstruction and less than half are satisfied with how they look unclothed. Breast conservation (removing the area with the lump only) can offer less…

Neo-tAnGo

This trial was trying to find the best combination of drugs to treat women who have chemotherapy before surgery for breast cancer. This trial was supported by Cancer Research UK.

Doctors sometimes treat breast cancer with chemotherapy…

PARTNER

Surgery is often used for early breast cancers however sometimes chemotherapy is given before surgery. This is called neoadjuvant chemotherapy, which can shrink the cancer and make surgery more successful. In this trial, researchers are looking…

PERSEPHONE

Monoclonal antibodies, such as trastuzumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. It is not yet…

PIONEER

Around 75% of breast cancers are defined and driven by Oestrogen receptor alpha (ERα) transcriptional activity. Standard treatment is endocrine therapy however clinical outcomes vary considerably, and a proportion of women with early breast…

PRaM-GBM

Brain tumours are the leading cause of cancer deaths in children, men under the age of 45 and women under the age of 25. Glioblastoma is the most common and most malignant primary tumour. The predominant treatment is surgical removal of the…

PREMIUM

Information coming soon.

PRICKLE

Pancreatic cancer is difficult to treat, and even in a situation where an operation can be performed to remove the cancer, the disease can unfortunately come back soon afterwards. When pancreatic cancer is more advanced, the outcomes are even…

SEIGE

Metastatic pancreatic cancer is difficult to treat. Until recently, most patients would be offered treatment with a chemotherapy drug called gemcitabine. However, a large international trial showed that combining gemcitabine with a drug called…

TAPS01

The numbers of men diagnosed with prostate cancer in the United Kingdom (UK) and worldwide is increasing. In the UK 46,690 men were diagnosed in 2014 alone and it is estimated this figure will be closer to 70,000 by 2030. A significant proportion…

UK P3BEP

Germ cell tumours (GCTs) account for 98% of all testicular cancers. Germ cell tumours also arise in the ovary, accounting for 1% to 2% of ovarian neoplasms. Germ cell tumours also rarely arise in the mediastinum, retroperitoneum, ovary and brain…

WIRE

A Phase 2, multi-arm, multicentre, non-randomised, proof-of-mechanism (single and combination IMPs) trial using a Bayesian adaptive design. A multi-centre trial. 2 centres initially planned - this may be reduced or increased in order to recruit…