Cancer trials

Renal cell carcinoma (RCC) is diagnosed in over 6000 patients and accounts for approximately 2% of malignant disease annually in the UK. Many patients initially present with advanced or unresectable disease and up to 30% of patients treated by…

Worldwide breast cancer poses a major healthcare problem. Considerable improvements in the treatment of the disease both in the adjuvant and in the metastatic setting have contributed to recent reductions in mortality. Although much of this…

AZD6738 is a potent, selective inhibitor of the serine (Ser)/threonine (Thr)-specific protein kinase, ataxia telangiectasia and Rad3-related protein (ATR), with good selectivity against other phosphatidylinositol 3-kinase-related kinase (PIKK)…

The worldwide incidence of melanoma is rising faster than that of any other malignancy, making it a major public health issue. Resection of primary melanomas offers a significant chance of cure. However, melanomas invade and metastasise early and…

Patients with newly diagnosed invasive breast cancer require their axillary lymph node status to be histologically established. 28,786 axillary staging procedures were performed in the UK in 2007. Standard practice is to perform this surgically…

In the absence of resectability, pancreatic ductal adenocarcinoma (PDAC) is almost uniformly lethal; therefore there is a great need to identify novel therapeutic approaches. Only 10-20% of patients present with operable disease and with addition…

Brain metastases occur in 20% to 40% of all patients with cancer, with an incidence 10 times higher than that of primary malignant brain tumours. Patients with brain metastases are an underserved population. Overall, they have a poor prognosis…

In the UK prostate cancer is the 4th most common cause of cancer death (accounting for 7% of total cancer deaths). Furthermore, in men, it is the 2nd most common cause of cancer death after lung cancer and accounts for 13% of cancer deaths. …

Despite recent advances in CRPC treatment, there remains an unmet medical need to identify those patients with early prostate cancer who are at greatest risk of relapse following treatment with curative intent and to optimize additional therapy.…

To date, despite the increasing use of capecitabine in patients with pancreatic cancer, formal pharmacokinetic (PK) studies have not been undertaken in patients who have undergone proximal pancreatico-duodenectomy. Although the use of…

This is a clinical trial to evaluate the pharmacokinetics (PK) of adjuvant capecitabine in patients who have undergone a total gastrectomy. The study will compare the pharmacokinetic profile of capecitabine administered to patients with gastric…

COVID-19 targets the body's respiratory system, where infections can be found in the nose, throat and lungs. The effect of COVID-19 infection is very variable, where many people might not know that they have been infected and have recovered from…

Carcinoma of the Oesophagus and stomach are respectively the 5th and 7th most common causes of death from cancer in the UK, between them accounting for more than 12,500 deaths per annum, more than any other individual cancer site apart from lung…

This study focuses on a form of blood cancer called lymphoma, the most common subtype of which is Diffuse Large B Cell Lymphoma (DLBCL). DLBCL is curable with chemotherapy in approximately 60% of patients. However, 40% of patients either fail to…

Pancreatic cancer is the fourth leading cause of cancer-related deaths in Western countries. It is a lethal disease that typically presents late, metastasises early and is resistant to conventional treatments such as radiation and chemotherapy.…

Brain tumours (gliomas) are classified as low and high-grade. Correctly distinguishing high-grade glioma (HGG) from low-grade glioma (LGG) during surgery can influence the surgical procedure, enhancing resection and improving survival. The aim of…

Pazopanib is a new cancer drug that works by limiting the growth of new blood vessels in tumours. Many patients who take pazopanib develop high blood pressure (hypertension). This side effect can make patients have to reduce or stop their cancer…

Melanoma is the most lethal form of skin cancer: over 13,000 patients are diagnosed in the United Kingdom (UK) annually. Although the majority of patients are diagnosed with primary tumours that can be removed by surgery, around 20% will relapse…

7-20% of gastric or oesophageal adenocarcinomas are known to over-express HER-2. Our data suggests that in vitro molecular over-expression of HER-2 is associated with the ligand independent constitutive phosphorylation of both HER-2 and EGFR…

Taking as reference tumour-specific somatic genetic alterations identified within individual cancer biopsies from patients, recent advances in genomic and next generation sequencing technologies now provide the opportunity to investigate whether…

Around 60-70% of the breast cancers are oestrogen receptor-positive (ER) and these cancers respond to anti-oestrogen therapy (response rate 30-70%). Post-menopausal women achieve a smaller benefit from chemotherapy as demonstrated by the Early…

Four in 10 women diagnosed with breast cancer undergo mastectomy with or without breast reconstruction and less than half are satisfied with how they look unclothed. Breast conservation (removing the area with the lump only) can offer less…

Renal cell carcinoma (RCC) is diagnosed in over 6000 patients and accounts for approximately 2% of malignant disease annually in the UK. Many patients initially present with advanced or unresectable disease and furthermore up to 30% of patients…

The incidence of breast cancer continues to rise in the US and Western Europe and breast cancer remains a major health problem despite considerable improvements in the treatment of the disease both in the adjuvant and in the metastatic setting,…

Neuroendocrine tumours (NETs) are very rare cancers, incidence around 1-2/100,000/year, with characteristically indolent behaviour. The mainstay of treatment is surgical resection. However, many tumours metastasise and cannot be removed, while…

Breast cancer is the most common female cancer worldwide, and the second most common cancer overall, with more than 1,676,000 newly diagnosed in 2012 (25% of female cancer cases and 12% of the total). Although advances in screening, surgical…

Metastatic pancreatic ductal adenocarcinoma (mPDA) is an aggressive form of cancer with very poor outcomes. It is generally treated with traditional chemotherapy but even…

The incidence of breast cancer continues to rise in Western Europe and the US with breast cancer remaining a major health problem despite considerable improvements in treatment of the disease both in the adjuvant and in the metastatic setting.…

Breast cancer is the most common cancer in women worldwide, and the second most common cancer overall, with more than 1,676,000 people newly diagnosed in 2012 (25% of all female cancer cases and 12% of the total). Although advances in screening,…

Brain tumours are the leading cause of cancer deaths in children, men under the age of 45 and women under the age of 25. Glioblastoma is the most common and most malignant primary tumour. The predominant treatment is surgical removal of the…

Treatment for melanoma patients is rapidly evolving, as new systemic therapies are improving outcomes in both the metastatic and adjuvant setting. Three key international randomised trials evaluating both immune checkpoint inhibitors and…

In the absence of resectability, pancreatic ductal adenocarcinoma (PDAC) is almost uniformly lethal; therefore there is a great need to optimize novel therapeutic approaches. Only around 10-20% of patients present with operable disease and with…

Pancreatic ductal adenocarcinoma (PDAC) is responsible for 32,500 deaths per year in Europe. In the absence of resectable disease, it is almost uniformly lethal. Only around 10-20% of patients present with operable disease and with the addition…

The numbers of men diagnosed with prostate cancer in the United Kingdom (UK) and worldwide is increasing. In the UK 46,690 men were diagnosed in 2014 alone and it is estimated this figure will be closer to 70,000 by 2030. A significant proportion…

Study design
TAPS02 is a phase 3, randomised, multicentre, double-blind, placebo-controlled trial investigating the use of short-term androgen targeted therapy (sATT) in the form of apalutamide (Erleada) in men on active…

Germ cell tumours of the testis are the most common malignancy affecting adolescent and young adult males in Australia and many other Western countries, with a disproportionally high amount of healthy life lost each year due to the early age at…

Radiotherapy (RT) is one of the most potent and cost-effective curative treatments for cancer. In the United Kingdom, about 300,000 new cancer cases occur each year. Around 50% of patients require radiotherapy at some time in their illness, and…

Renal cell cancer (RCC) is the 7th commonest cancer in the UK (12,500 new cases/year) and the most lethal of the urological malignancies with a 50% 10-year survival when considering all patients. Vascular endothelial growth factor (VEGF) tyrosine…