Core trials

Trials open to recruitment

ATP

Depression affects over 300 million people globally and is one of the main causes of severe disability. Symptoms of depression often persist despite adequate antidepressant drug therapy, possibly because currently available antidepressant drugs…

CLOuD

The purpose of the study is to use a novel treatment approach, the artificial pancreas, after diagnosis of type 1 diabetes (T1D) to improve glucose control with the anticipated improvements of residual C-peptide secretion.

This is an open…

IASO

Ulcerative colitis (UC) is an inflammatory condition of the large bowel associated with diarrhoea, pain and bleeding that affects 120,000 people in the UK. Patients at the most severe extreme, who are hospitalised with acute severe UC (ASUC),…

PROFILE

Crohn’s disease is a type of inflammatory bowel disease (IBD) that can affect any part of the intestine. The severity of Crohn’s disease varies a lot between different people, and this means that what might be the best treatment for one person…

TAR:GET-1

Chronic antibody-mediated rejection (cAMR) is the leading cause of kidney transplant failure. Fifty percent of kidney transplant patients who develop acute antibody-mediated rejection (aAMR) will develop evidence of cAMR within 1 year of the…

The SIMPLIFIED Registry Trial

Vitamin D deficiency is common in kidney failure, and is a strong predictor of death from cardiovascular disease, infections and cancer. Dialysis patients typically receive pre-activated vitamin D, since it used to be thought that only the…

TURING

Minimal Change Disease (MCD) and Focal Segmental Glomerular Sclerosis (FSGS) are rare diseases that damage kidneys in a similar way, causing protein leakage into the urine with severe swelling of the legs and face. Serious complications can arise…