Core trials

Trials open to recruitment

ATP

According to the World Health Organization (http://www.who.int), more than 300 million people suffer from depression globally, equivalent to a lifetime prevalence of 7 to 12% for men and 20 to 25% for women. MDD is the leading cause of disability…

CETO

At least one-quarter of the UK adult population has hypertension, which is a major risk factor for heart attacks and stroke. Primary aldosteronism (PA), a treatable form of hypertension, accounts for 5-10% of all cases, and 20-25% of those with…

CLOuD

Management of newly diagnosed T1D in children and adolescents is challenging for patients, families, carers, and health care professionals. Glucose is the dominant metabolic substrate for brain function and the glycaemic instability inherent in…

IASO

Ulcerative colitis (UC) is an inflammatory condition of the large bowel associated with diarrhoea, pain and bleeding that affects 120,000 people in the UK. Patients at the most severe extreme, who are hospitalised with acute severe UC (ASUC),…

PROFILE

Crohn’s disease (CD) is a relapsing-remitting form of inflammatory bowel disease (IBD) that can affect any part of the intestinal tract, most commonly the ileum and the colon. It is a common condition, affecting at least 115,000 people in the…

TAR:GET-1

Kidney transplantation is the treatment of choice for most patients with end-stage kidney disease (ESKD), resulting in improved health and patient survival, quality of life and health economic benefit in comparison to remaining on dialysis. The…

The SIMPLIFIED Registry Trial

In the United Kingdom, nearly 30,000 people receive regular dialysis and 6,000 new patients start dialysis each year. Although this is a life-saving treatment, dialysis-requiring renal failure carries a worse prognosis than most malignancies, …

TURING

Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS) are auto-immune renal diseases that present with a common clinical phenotype, the nephrotic syndrome (NS), characterised by heavy proteinuria and debilitating oedema. When…