Core trials

Management of newly diagnosed T1D in children and adolescents is challenging for patients, families, carers, and health care professionals. Glucose is the dominant metabolic substrate for brain function and the glycaemic instability inherent…

Periportal fibrosis is the severest pathology caused by schistosomiasis mansoni. Large fibrotic deposits in the liver can lead to portal hypertension and death by haematemesis. The cornerstone of disease control is annual preventative…

For patients with chronic diseases such as neurodegenerative disorders and immune-mediated inflammatory diseases, a key attribute for any successful therapeutic intervention is its ability to improve the patients’ activities of daily living…

PROTECT-V is an international, multicentre study aiming to identify medications which protect vulnerable patients from COVID-19. The trial is enrolling participants who are at particularly high risk of COVID-19 and its complications. We are…

This research aims to develop a scalable, inclusive, and sustainable model for remote ophthalmic consultations integrating vision self-testing through the DigiVis app. With…

Minimal Change Disease (MCD) and Focal Segmental Glomerulosclerosis (FSGS) are auto-immune renal diseases that present with a common clinical phenotype, the nephrotic syndrome (NS), characterised by heavy proteinuria and debilitating oedema. When…