Core trials

AceFIT

Approximately 1,500 older people break the pelvic part of their hip joint (acetabulum) each year in the UK. These fractures are challenging in older patients as the bone is often fragile and in many pieces. There are 2 main accepted treatment…

ATP

Depression affects over 300 million people globally and is one of the main causes of severe disability. Symptoms of depression often persist despite adequate antidepressant drug therapy, possibly because currently available antidepressant drugs…

AZA-PD

Immune activation is strongly implicated in a number of neurodegenerative diseases, including Parkinson’s disease (PD) and related Parkinson-Plus disorders. Our own work has demonstrated not only that there is a genetic link between the immune…

CAM-THY

The purpose of this study is to prevent the main side effects of alemtuzumab a drug with great promise as a treatment of multiple sclerosis. If this can be achieved, then greater numbers of people could access the benefits of the drug. In…

CETO PET

At least one quarter of the adult UK population has hypertension, a major risk factor for heart attacks and stroke. Primary hyperaldosteronism (PHA), a treatable form of hypertension, accounts for 5-10% of all cases, and 20-25% of those with…

CLOuD

The purpose of the study is to use a novel treatment approach, the artificial pancreas, after diagnosis of type 1 diabetes (T1D) to improve glucose control with the anticipated improvements of residual C-peptide secretion.

This is an open…

DILfrequency

Type 1 diabetes (T1D) is the most common severe chronic autoimmune disease worldwide with a rapidly increasing incidence and prevalence, occuring in adults and children equally. The aetiology of T1D is an autoimmune (loss of self-tolerance)…

DRINK

Autosomal Dominant Polycystic Kidney Disease (PKD) affects 12.5 million people worldwide, and accounts for 7% of those requiring renal replacement therapy. The hormone vasopressin drives cyst growth until ultimately most of the normal functioning…

E-Vac

Information coming soon.

FibroScHot

A substantial proportion of the world’s disease burden is caused by infectious agents that lead to high mortality, morbidity, and reduced productivity among many millions of people and their animals. Guided by the Millennium Development Goals (…

HELP-K

Information coming soon.

IASO

Ulcerative colitis (UC) is an inflammatory condition of the large bowel associated with diarrhoea, pain and bleeding that affects 120,000 people in the UK. Patients at the most severe extreme, who are hospitalised with acute severe UC (ASUC),…

IDEA-FAST

For patients with chronic diseases such as neurodegenerative disorders and immune-mediated inflammatory diseases, a key attribute for any successful therapeutic intervention is its ability to improve the patients’ activities of daily living (ADL…

KFORT

The knee is the largest weight-bearing joint in the body, where the shin bone (tibia) and thigh bone (femur) meet. As we get older our bones naturally weaken, and so the elderly are particularly vulnerable to knee pain and injury. Every year,…

PROFILE

Crohn’s disease is a type of inflammatory bowel disease (IBD) that can affect any part of the intestine. The severity of Crohn’s disease varies a lot between different people, and this means that what might be the best treatment for one person…

RECEDE

Information coming soon.

TAR:GET-1

Chronic antibody-mediated rejection (cAMR) is the leading cause of kidney transplant failure. Fifty percent of kidney transplant patients who develop acute antibody-mediated rejection (aAMR) will develop evidence of cAMR within 1 year of the…

The SIMPLIFIED Registry Trial

Vitamin D deficiency is common in kidney failure, and is a strong predictor of death from cardiovascular disease, infections and cancer. Dialysis patients typically receive pre-activated vitamin D, since it used to be thought that only the…

TURING

Minimal Change Disease (MCD) and Focal Segmental Glomerular Sclerosis (FSGS) are rare diseases that damage kidneys in a similar way, causing protein leakage into the urine with severe swelling of the legs and face. Serious complications can arise…