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2020
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Vascular Positron Emission Tomography and Restenosis in Symptomatic Peripheral Arterial Disease
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Peri-Operative Hyperkalaemia in Decreased-Donor Kidney Translpant Recipients
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Evaluating Pain in Autosomal Dominant Polycystic Kidney Disease
- Discussion and documentation of future care: a before-and-after study examining the impact of an alternative approach to recording treatment decisions on advance care planning in an acute hospital
- Drains result in greater reduction of subdural width and midline shift in burr hole evacuation of chronic subdural haematoma
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ctDNA monitoring using patient-specific sequencing and integration of variant reads
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Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis
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Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy
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ChemoPROphyLaxIs For covId-19 infeCtious disease (the PROLIFIC trial)
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Advances in PET to assess pulmonary inflammation: A systematic review
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Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation
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OP0058-PARE My Sjögren's Diary: An online Patient Portal for Patient Led Sjögren's Syndrome Research
- Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
- Systematic review of current randomised control trials in chronic subdural haematoma and proposal for an international collaborative approach.
- Cardiovascular Functional Reserve Before and After Kidney Transplant
- Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study
- High water vs. ad libitum water intake for autosomal dominant polycystic kidney disease: a randomized controlled feasibility trial
- Aortic Pulse Wave Velocity Predicts All-cause Mortality in Chronic Obstructive Pulmonary Disease
- Health professionals' views about who would benefit from using a closed-loop system: a qualitative study
- What Training, Support, and Resourcing Do Health Professionals Need to Support People Using a Closed-Loop System? A Qualitative Interview Study with Health Professionals Involved in the Closed Loop from Onset in Type 1 Diabetes (CLOuD)Trial
- Legal and ethical framework for global health information and biospecimen exchange - an international perspective
- A quantitative analysis of the spatial and temporal evolution patterns of the bluetongue virus outbreak in the island of Lesvos, Greece, in 2014
- Geospatial and Clinical Factors Associated with Frequent Emergency Department Use at a Washington DC Safety Net Hospital
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2019
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Time to surgery following chronic subdural hematoma: post hoc analysis of a prospective cohort study
- 6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial
- Academic neurosurgery in the UK: present and future directions
- The effect of sleep deprivation and exercise on reaction threshold in peanut-allergic adults: a randomised controlled study
- Hyperphosphataemia in 2019: have we made progress?
- A randomised, double-blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial
- Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2)
- A zero coronary artery calcium score in patients with stable chest pain is associated with a good prognosis, despite risk of non-calcified plaques
- Keratinocyte growth factor impairs human thymic recovery from lymphopenia
- Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma: report of the internal pilot phase
- Vitamin D and Atherosclerotic Cardiovascular Disease
- Correction to: Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial
- Non-invasive measurements of arterial function: What? When? Why should we use them?
- Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial
- Elucidating fitness components of the invasive dermestid beetle Trogoderma granarium combining deterministic and stochastic demography
- Mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA-associated vasculitis: a randomised, non-inferiority trial
- Influence of Antiplatelet and Anticoagulant Drug Use on Outcomes after Chronic Subdural Hematoma Drainage
- No Surgical Innovation Without Evaluation: Evolution and Further Development of the IDEAL Framework and Recommendations
- How to design a dose-finding study using the continual reassessment method
- Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis
- Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.
- Effect of sleep deprivation and exercise on reaction threshold in adults with peanut allergy: A randomized controlled study
- Knee Fix or Replace Trial (KFORT): a randomized controlled feasibility study
- Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers - a mechanistic physiological study (INTENSITY-LOW): protocol and study rationale
- Contemporary statistical inference for infectious disease models using Stan
- Trajectories of Haemoglobin and incident stroke risk: a longitudinal cohort study
- Anatomical change during radiotherapy for head and neck cancer, and its effect on delivered dose to the spinal cord
- Statistical analysis plan for the Dex-CSDH trial: a randomised, double-blind, placebo-controlled trial of a 2-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematoma
- Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop
- Theory of general balance applied to step wedge designs
- Does Drain Position and Duration Influence Outcomes in Patients Undergoing Burr-Hole Evacuation of Chronic Subdural Hematoma? Lessons from a UK Multicenter Prospective Cohort Study
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2018
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- Metformin in non-diabetic hyperglycaemia: the GLINT feasibility RCT
- Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry
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Safety and efficacy of low-dose sirolimus in the PIK3CA-related overgrowth spectrum
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Aspirin does not prevent growth of vestibular schwannomas: A case‐control study
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Inverting the patient involvement paradigm: defining patient led research
- Randomised controlled trial of high versus ad libitum water intake in patients with autosomal dominant polycystic kidney disease: rationale and design of the DRINK feasibility trial
- Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY - 2 mechanisms substudies
- Quality of stepped-wedge trial reporting can be reliably assessed using an updated CONSORT: crowd-sourcing systematic review
- Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial
- The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes
- Pharmacological management of post-traumatic seizures in adults: current practice patterns in the UK and the Republic of Ireland
- Targeting glucose control in preterm infants: pilot studies of continuous glucose monitoring
- Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase I/II clinical trial
- A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial
- Protocol of a randomised controlled trial of real-time continuous glucose monitoring in neonatal intensive care 'REACT'
- Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease
- Identifying risk factors for L'Hermitte's sign after IMRT for head and neck cancer
- Outcomes following surgery in subgroups of comatose and very elderly patients with chronic subdural hematoma
- Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study
- The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial
- PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial
- The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness
- The British Neurosurgical Trainee Research Collaborative: Five years on
- Brain tumor research in the United Kingdom: current perspective and future challenges. A strategy document from the NCRI Brain Tumor CSG
- DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial
- Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study
- Cost-Effectiveness and Value of Information Analysis of Brief Interventions to Promote Physical Activity in Primary Care
- Local alkylating chemotherapy applied immediately after 5-ALA guided resection of glioblastoma does not provide additional benefit
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2017
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Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2
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Detection of Atherosclerotic Inflammation by 68Ga-DOTATATE PET Compared to [18F]FDG PET Imaging
- ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes
- Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): urinary screening and baseline biochemical and cardiovascular assessments.
- Survival Trends After Surgery for Acute Subdural Hematoma in Adults Over a 20-year Period.
- Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies.
- Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation.
- Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers.
- Addition of gemcitabine to paclitaxel, epirubicin, and cyclophosphamide adjuvant chemotherapy for women with early-stage breast cancer (tAnGo): final 10-year follow-up of an open-label, randomised, phase 3 trial.
- Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years.
- Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary ‘VoxTox’ research programme.
- A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease: Rationale and design of the SPIRO-CKD trial.
- The INVEST project: investigating the use of evidence synthesis in the design and analysis of clinical trials
- Improving the External Validity of Clinical Trials in Dialysis Populations
- Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography
- rpsftm: An R Package for Rank Preserving Structural Failure Time Models
- Central pathology review with two-stage quality assurance for pathological response after neoadjuvant chemotherapy in the ARTemis Trial
- Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse
- Microbubble detection and ultrasound-guided vacuum-assisted biopsy of axillary lymph nodes in patients with breast cancer
- Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma
- Delivered dose can be a better predictor of rectal toxicity than planned dose in prostate radiotherapy
- Patient Survey of current water Intake practices in autosomal dominant Polycystic kidney disease: the SIPs survey
- Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial
- Disease-free and overall survival at 3.5 years for neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin and cyclophosphamide, for women with HER2 negative early breast cancer: ARTemis Trial
- 2016
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Decompressive craniectomy following traumatic brain injury: developing the evidence base
- Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study.
- Core Outcomes and Common Data Elements in Chronic Subdural Hematoma: A Systematic Review of the Literature Focusing on Baseline and Peri-Operative Care Data Elements.
- Surgical trainee research collaboratives in the UK: an observational study of research activity and publication productivity.
- Trastuzumab-associated cardiac events in the Persephone trial.
- Accumulated Dose to the Rectum, Calculated from Auto-contoured Image Guidance CT Scans, is Lower than Planned Dose in the Majority of Patients Treated with Radiotherapy for Prostate Cancer
- Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial.
- Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer.
- The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case- Control Study.
- Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis.
- Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.
- Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.
- The Cambridge Breast Intensity-modulated Radiotherapy Trial: Comparison of Clinician-versus-Patient-reported Outcomes
- Detection of colorectal dysplasia using fluorescently labelled lectins
- Core Outcomes and Common Data Elements in Chronic Subdural Hematoma: A Systematic Review of the Literature Focusing on Reported Outcomes
- 2015
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Vitamin K Antagonists Predispose to Calciphylaxis in Patients with End-Stage Renal Disease
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The 3+3 versus model-based approach: implementation in the CAPCISUM pancreatic cancer trial
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Using the UK renal registry for a clinical trial in dialysis patients: the example of SIMPLIFIED
- Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study
- Ipilimumab in the real world: the UK expanded access programme experience in previously treated advanced melanoma patients.
- A Comparison of Outcomes Following Laparoscopic and Open Hysterectomy With or Without Lymphadenectomy for Presumed Early-Stage Endometrial Cancer: Results From the Medical Research Council ASTEC Trial
- Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial.
- A Bayesian adaptive design for biomarker trials with linked treatments.
- Neoadjuvant Trials in Early Breast Cancer: Pathological Response at Surgery and Correlation to Longer Term Outcomes – What does it all mean?
- A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities.
- Molecular effects of Lapatinib in the treatment of HER2 overexpressing oesophago-gastric adenocarcinoma.
- Efficacy of neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide, for women with HER2-negative early breast cancer (ARTemis): an open-label, randomised, phase 3 trial.
- Bevacizumab: the phoenix of breast oncology?
- The power of phase II end-points for different possible mechanisms of action of an experimental treatment.
- Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma.
- Surgeon-specific mortality data disguise wider failings in delivery of safe surgical services.
- Arterial Expression of the Calcium-Sensing Receptor Is Maintained by Physiological Pulsation and Protects against Calcification
- Accumulated dose to the rectum, measured using dose-volume histograms and dose-surface maps, is different from planned dose in all patients treated with radiotherapy for prostate cancer
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Comparison of analysis approaches for multi-level vascular imaging data
- 2014
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Evaluating the Role of Inflammation in Chronic Airways Disease: The ERICA Study
- Ritiximab versus a watch-and-wait approach in patients with advanced-stage, asymptomatic, non-bulky follicular lymphoma: an open-label randomised phase 3 trial.
- Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel.
- Study of induction of Tolerance to Oral Peanut: a randomised controlled trial of desensitisation using peanut oral immunotherapy in children (STOP II).
- Twist-drill craniostomy with hollow screws for evacuation of chronic subdural hematoma.
- Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trial.
- Adjuvant bevacizumab in patients with melanoma at high risk of recurrence (AVAST-M): preplanned interim results from a multicentre, open-label, randomised controlled phase 3 study.
- Optimal treatment of early-stage ovarian cancer.
- Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial.
- Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease.
- Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial.
- Patient reported outcome measures (PROMs) following forward planned field-in field IMRT: results from the Cambridge Breast IMRT trial.
- Rituximab versus a watch-and-wait approach in patients with advanced-stage, asymptomatic, non-bulky follicular lymphoma: an open-label randomised phase 3 trial.
- Chronic dipeptidyl peptidase-4 inhibition with sitagliptin is associated with sustained protection against ischemic left ventricular dysfunction in a pilot study of patients with type 2 diabetes mellitus and coronary artery disease.
- Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial.
- The Cambridge post-mastectomy radiotherapy (C-PMRT) index: a practical tool for patient selection.
- Capecitabine and streptozocin ± cisplatin in advanced gastroenteropancreatic neuroendocrine tumours.
- Effects of the addition of gemcitabine, and paclitaxel-first sequencing, in neoadjuvant sequential epirubicin, cyclophosphamide, and paclitaxel for women with high-risk early breast cancer (Neo-tAnGo): an open-label, 2×2 factorial randomised phase 3 trial.
- Pre-dialysis systolic blood pressure-variability is independently associated with all-cause mortality in incident haemodialysis patients.
- Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial.
- Central blood pressure: current evidence and clinical importance.
- 2013
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- Standard chemotherapy with or without bevacizumab in advanced ovarian cancer: quality-of-life outcomes from the International Collaboration on Ovarian Neoplasms (ICON7) phase 3 randomised trial.
- Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles.
- A central review of histopathology reports after breast cancer neoadjuvant chemotherapy in the neo-tango trial
- Is community treatment best? a randomised trial comparing delivery of cancer treatment in the hospital, home and GP surgery.
- ACE inhibitor and angiotensin receptor-II antagonist prescribing and hospital admissions with acute kidney injury: a longitudinal ecological study.
- Treatment costs associated with interventional cancer clinical trials conducted at a single UK institution over 2 years (2009-2010).
- Stepped wedge cluster randomized trials are efficient and provide a method of evaluation without which some interventions would not be evaluated
- 2012
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- Low absolute bioavailability of oral naloxone in healthy subjects.
- A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications.
- Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials.
- 2011
- 2010
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