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2020
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- Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
- Systematic review of current randomised control trials in chronic subdural haematoma and proposal for an international collaborative approach.
- Cardiovascular Functional Reserve Before and After Kidney Transplant
- Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study
- High water vs. ad libitum water intake for autosomal dominant polycystic kidney disease: a randomized controlled feasibility trial
- Aortic Pulse Wave Velocity Predicts All-cause Mortality in Chronic Obstructive Pulmonary Disease
- Health professionals' views about who would benefit from using a closed-loop system: a qualitative study
- What Training, Support, and Resourcing Do Health Professionals Need to Support People Using a Closed-Loop System? A Qualitative Interview Study with Health Professionals Involved in the Closed Loop from Onset in Type 1 Diabetes (CLOuD)Trial
- Legal and ethical framework for global health information and biospecimen exchange - an international perspective
- A quantitative analysis of the spatial and temporal evolution patterns of the bluetongue virus outbreak in the island of Lesvos, Greece, in 2014 Drains result in greater reduction of subdural width and midline shift in burr hole evacuation of chronic subdural haematoma
- Geospatial and Clinical Factors Associated with Frequent Emergency Department Use at a Washington DC Safety Net Hospital
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2019
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- 6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial
- Academic neurosurgery in the UK: present and future directions
- The effect of sleep deprivation and exercise on reaction threshold in peanut-allergic adults: a randomised controlled study
- Hyperphosphataemia in 2019: have we made progress?
- A randomised, double-blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial
- Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2)
- A zero coronary artery calcium score in patients with stable chest pain is associated with a good prognosis, despite risk of non-calcified plaques
- Keratinocyte growth factor impairs human thymic recovery from lymphopenia
- Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma: report of the internal pilot phase
- Vitamin D and Atherosclerotic Cardiovascular Disease
- Correction to: Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial
- Non-invasive measurements of arterial function: What? When? Why should we use them?
- Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial
- Elucidating fitness components of the invasive dermestid beetle Trogoderma granarium combining deterministic and stochastic demography
- Mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA-associated vasculitis: a randomised, non-inferiority trial
- Influence of Antiplatelet and Anticoagulant Drug Use on Outcomes after Chronic Subdural Hematoma Drainage
- No Surgical Innovation Without Evaluation: Evolution and Further Development of the IDEAL Framework and Recommendations
- How to design a dose-finding study using the continual reassessment method
- Biomarkers and clinical outcomes in COPD: a systematic review and meta-analysis
- Vitamin D and Atherosclerotic Cardiovascular Disease
- No Surgical Innovation Without Evaluation: Evolution and Further Development of the IDEAL Framework and Recommendations.
- Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.
- Effect of sleep deprivation and exercise on reaction threshold in adults with peanut allergy: A randomized controlled study
- Knee Fix or Replace Trial (KFORT): a randomized controlled feasibility study
- Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers - a mechanistic physiological study (INTENSITY-LOW): protocol and study rationale
- Contemporary statistical inference for infectious disease models using Stan
- Trajectories of Haemoglobin and incident stroke risk: a longitudinal cohort study
- Anatomical change during radiotherapy for head and neck cancer, and its effect on delivered dose to the spinal cord
- Statistical analysis plan for the Dex-CSDH trial: a randomised, double-blind, placebo-controlled trial of a 2-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematoma
- Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop
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2018
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- Randomised controlled trial of high versus ad libitum waterintake in patients with autosomal dominant polycystic kidney disease: rationale and design of the DRINK feasibility trial
- Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY - 2 mechanisms substudies
- Quality of stepped-wedge trial reporting can be reliably assessed using an updated CONSORT: crowd-sourcing systematic review
- Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial
- The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes
- Pharmacological management of post-traumatic seizures in adults: current practice patterns in the UK and the Republic of Ireland
- Targeting glucose control in preterm infants: pilot studies of continuous glucose monitoring
- Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase I/II clinical trial
- Theory of general balance applied to step wedge designs
- Does Drain Position and Duration Influence Outcomes in Patients Undergoing Burr-Hole Evacuation of Chronic Subdural Hematoma? Lessons from a UK Multicenter Prospective Cohort Study
- A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial
- Protocol of a randomised controlled trial of real-time continuous glucose monitoring in neonatal intensive care 'REACT'
- Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease
- Randomised controlled trial of high versus ad libitum water intake in patients with autosomal dominant polycystic kidney disease: rationale and design of the DRINK feasibility trial
- Identifying risk factors for L'Hermitte's sign after IMRT for head and neck cancer
- Outcomes following surgery in subgroups of comatose and very elderly patients with chronic subdural hematoma
- Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study
- The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial
- ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes
- PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial
- A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial.
- The matrix proteins aggrecan and fibulin-1 play a key role in determining aortic stiffness
- The British Neurosurgical Trainee Research Collaborative: Five years on
- Brain tumor research in the United Kingdom: current perspective and future challenges. A strategy document from the NCRI Brain Tumor CSG
- DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial
- Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease: A Large Case-Controlled Study
- Cost-Effectiveness and Value of Information Analysis of Brief Interventions to Promote Physical Activity in Primary Care
- Local alkylating chemotherapy applied immediately after 5-ALA guided resection of glioblastoma does not provide additional benefit
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2017
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- Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT): urinary screening and baseline biochemical and cardiovascular assessments.
- Survival Trends After Surgery for Acute Subdural Hematoma in Adults Over a 20-year Period.
- Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies.
- Quantitative analysis of dynamic 18F-FDG PET/CT for measurement of lung inflammation.
- Informing efficient randomised controlled trials: exploration of challenges in developing progression criteria for internal pilot studies
- Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers.
- Addition of gemcitabine to paclitaxel, epirubicin, and cyclophosphamide adjuvant chemotherapy for women with early-stage breast cancer (tAnGo): final 10-year follow-up of an open-label, randomised, phase 3 trial.
- Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years.
- Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary ‘VoxTox’ research programme.
- A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease: Rationale and design of the SPIRO-CKD trial.
- The INVEST project: investigating the use of evidence synthesis in the design and analysis of clinical trials
- Improving the External Validity of Clinical Trials in Dialysis Populations
- Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography
- rpsftm: An R Package for Rank Preserving Structural Failure Time Models
- Central pathology review with two-stage quality assurance for pathological response after neoadjuvant chemotherapy in the ARTemis Trial
- Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse
- Microbubble detection and ultrasound-guided vacuum-assisted biopsy of axillary lymph nodes in patients with breast cancer
- Analysis of heterogeneity in T2-weighted MR images can differentiate pseudoprogression from progression in glioblastoma
- Delivered dose can be a better predictor of rectal toxicity than planned dose in prostate radiotherapy
- Patient Survey of current water Intake practices in autosomal dominant Polycystic kidney disease: the SIPs survey
- Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial
- Discussion and documentation of future care: a before-and-after study examining the impact of an alternative approach to recording treatment decisions on advance care planning in an acute hospital
- Disease-free and overall survival at 3.5 years for neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin and cyclophosphamide, for women with HER2 negative early breast cancer: ARTemis Trial
- Protocol of the adaptive study of IL-2 dose frequency on regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non-randomised, repeat dose, open-label, response-adaptive study
- 2016
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- Exploratory Analysis of TP53 Mutations in Circulating Tumour DNA as Biomarkers of Treatment Response for Patients with Relapsed High-Grade Serous Ovarian Carcinoma: A Retrospective Study.
- Core Outcomes and Common Data Elements in Chronic Subdural Hematoma: A Systematic Review of the Literature Focusing on Baseline and Peri-Operative Care Data Elements.
- Surgical trainee research collaboratives in the UK: an observational study of research activity and publication productivity.
- Trastuzumab-associated cardiac events in the Persephone trial.
- Accumulated Dose to the Rectum, Calculated from Auto-contoured Image Guidance CT Scans, is Lower than Planned Dose in the Majority of Patients Treated with Radiotherapy for Prostate Cancer
- Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial.
- Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer.
- The Relationship between Common Genetic Markers of Breast Cancer Risk and Chemotherapy-Induced Toxicity: A Case- Control Study.
- Tetrahydrobiopterin Supplementation Improves Endothelial Function But Does Not Alter Aortic Stiffness in Patients With Rheumatoid Arthritis.
- Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor.
- Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin- 2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial.
- The Cambridge Breast Intensity-modulated Radiotherapy Trial: Comparison of Clinician versus Patient-reported Outcomes
- Core Outcomes and Common Data Elements in Chronic Subdural Hematoma: A Systematic Review of the Literature Focusing on Reported Outcomes
- Detection of colorectal dysplasia using fluorescently labelled lectins
- 2015
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- Ipilimumab in the real world: the UK expanded access programme experience in previously treated advanced melanoma patients.
- A Comparison of Outcomes Following Laparoscopic and Open Hysterectomy With or Without Lymphadenectomy for Presumed Early-Stage Endometrial Cancer: Results From the Medical Research Council ASTEC Trial
- Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial.
- A Bayesian adaptive design for biomarker trials with linked treatments.
- Neoadjuvant Trials in Early Breast Cancer: Pathological Response at Surgery and Correlation to Longer Term Outcomes – What does it all mean?
- A nested cohort study of 6,248 early breast cancer patients treated in neoadjuvant and adjuvant chemotherapy trials investigating the prognostic value of chemotherapy-related toxicities.
- Molecular effects of Lapatinib in the treatment of HER2 overexpressing oesophago-gastric adenocarcinoma.
- Protocol of the adaptive study of IL-2 dose frequency in regulatory T cells in type 1 diabetes (DILfrequency): a mechanistic, non randomised, repeat dose, open label, response adaptive study.
- Ipilimumab in the real world: the UK expanded access programme experience in previously treated advanced melanoma patients.
- Efficacy of neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin, and cyclophosphamide, for women with HER2-negative early breast cancer (ARTemis): an open-label, randomised, phase 3 trial.
- Bevacizumab: the phoenix of breast oncology?
- The power of phase II end-points for different possible mechanisms of action of an experimental treatment.
- Endothelin-1 and endothelin B receptor expression in pancreatic adenocarcinoma.
- Surgeon-specific mortality data disguise wider failings in delivery of safe surgical services.
- Arterial Expression of the Calcium-Sensing Receptor Is Maintained by Physiological Pulsation and Protects against Calcification
- Accumulated dose to the rectum, measured using dose-volume histograms and dose-surface maps, is different from planned dose in all patients treated with radiotherapy for prostate cancer
- 2014
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- Ritiximab versus a watch-and-wait approach in patients with advanced-stage, asymptomatic, non-bulky follicular lymphoma: an open-label randomised phase 3 trial.
- Replication of genetic polymorphisms reported to be associated with taxane-related sensory neuropathy in patients with early breast cancer treated with Paclitaxel.
- Study of induction of Tolerance to Oral Peanut: a randomised controlled trial of desensitisation using peanut oral immunotherapy in children (STOP II).
- Twist-drill craniostomy with hollow screws for evacuation of chronic subdural hematoma.
- Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trial.
- Adjuvant bevacizumab in patients with melanoma at high risk of recurrence (AVAST-M): preplanned interim results from a multicentre, open-label, randomised controlled phase 3 study.
- Optimal treatment of early-stage ovarian cancer.
- Effects of oral lycopene supplementation on vascular function in patients with cardiovascular disease and healthy volunteers: a randomised controlled trial.
- Therapeutic potential of p38 MAP kinase inhibition in the management of cardiovascular disease.
- Rationale and study design of the Adaptive study of IL-2 dose on regulatory T cells in type 1 diabetes (DILT1D): a non-randomised, open label, adaptive dose finding trial.
- Patient reported outcome measures (PROMs) following forward planned field-in field IMRT: results from the Cambridge Breast IMRT trial.
- Rituximab versus a watch-and-wait approach in patients with advanced-stage, asymptomatic, non-bulky follicular lymphoma: an open-label randomised phase 3 trial.
- Chronic dipeptidyl peptidase-4 inhibition with sitagliptin is associated with sustained protection against ischemic left ventricular dysfunction in a pilot study of patients with type 2 diabetes mellitus and coronary artery disease.
- Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial.
- The Cambridge post-mastectomy radiotherapy (C-PMRT) index: a practical tool for patient selection. Capecitabine and streptozocin ± cisplatin in advanced gastroenteropancreatic neuroendocrine tumours.
- Effect of A Reduction in glomerular filtration rate after NEphrectomy on arterial STiffness and central hemodynamics: rationale and design of the EARNEST study.
- Effects of the addition of gemcitabine, and paclitaxel-first sequencing, in neoadjuvant sequential epirubicin, cyclophosphamide, and paclitaxel for women with high-risk early breast cancer (Neo-tAnGo): an open-label, 2×2 factorial randomised phase 3 trial.
- Pre-dialysis systolic blood pressure-variability is independently associated with all-cause mortality in incident haemodialysis patients.
- Docetaxel versus active symptom control for refractory oesophagogastric adenocarcinoma (COUGAR-02): an open-label, phase 3 randomised controlled trial.
- Central blood pressure: current evidence and clinical importance. Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial.
- 2013
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- Standard chemotherapy with or without bevacizumab in advanced ovarian cancer: quality-of-life outcomes from the International Collaboration on Ovarian Neoplasms (ICON7) phase 3 randomised trial.
- Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone in patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma: a phase 3 comparison of dose intensification with 14-day versus 21-day cycles.
- A central review of histopathology reports after breast cancer neoadjuvant chemotherapy in the neo-tango trial
- Is community treatment best? a randomised trial comparing delivery of cancer treatment in the hospital, home and GP surgery.
- ACE inhibitor and angiotensin receptor-II antagonist prescribing and hospital admissions with acute kidney injury: a longitudinal ecological study.
- Treatment costs associated with interventional cancer clinical trials conducted at a single UK institution over 2 years (2009-2010).
- Stepped wedge cluster randomized trials are efficient and provide a method of evaluation without which some interventions would not be evaluated
- 2012
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- Low absolute bioavailability of oral naloxone in healthy subjects.
- A randomised study evaluating the use of pyridoxine to avoid capecitabine dose modifications.
- Adjuvant epirubicin followed by cyclophosphamide, methotrexate and fluorouracil (CMF) vs CMF in early breast cancer: results with over 7 years median follow-up from the randomised phase III NEAT/BR9601 trials.
- 2011
- 2010
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