Publications

Listing of peer-reviewed journal article links is by year of journal issue, in line with citation recommendations. Published author replies and correspondence responses are not listed on this page.

2025

PROTECT-V

•  Prophylaxis for renal patients at risk of COVID-19 infection: results from the intranasal niclosamide randomised, double blinded, placebo controlled arm of the PROTECT-V platform trial 

2024

Affiliated Publications

• Metformin for preventing the progression of chronic kidney disease
• Trial to assess the tolerability of using felodipine to upregulate autophagy as a treatment of Huntington's disease (FELL-HD)
• Acetabular Fractures in older patients Intervention Trial (AceFIT): a feasibility triple-arm randomized controlled study
• The PARTNER trial of neoadjuvant olaparid in triple-negative breast cancer      
• Using healthcare systems data for outcomes in clinical trials: issues to consider at the design stage

PROFILE

• A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial - The Lancet Gastroenterology & Hepatology

 

2023

Affiliated Publications 

• Clinical and biological markers predictive of treatment response associated with metastatic pancreatic adenocarcinoma

• Myocardial performance index as a measure of global left ventricular function improves following isometric exercise training in hypertensive patients

• Can the diagnostic accuracy of newborn eye screening for congenital cataract be improved with digital imaging? The Digital Imaging versus Ophthalmoscopy (DIvO) study

• Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma

• Rituximab versus azathioprine for maintenance of remission for patients with ANCA-associated vasculitis and relapsing disease: an international randomised controlled trial

• Surgical outcomes of gallbladder cancer: the OMEGA retrospective, multicentre, international cohort study
• Comparison of three-weekly and six-weekly pembrolizumab United Kingdom prescribing practice for advanced and resected melanoma.
• Targeting patient recovery priorities in degenerative cervical myelopathy: design and rationale for the RECEDE-Myelopathy trial-study protocol
• Refining the Intraoperative Identification of Suspected High-Grade Glioma Using a Surgical Fluorescence Biomarker: GALA BIDD Study Report
• Efficacy and safety of baricitinib or ravulizumba in adult patients with severe COVID-19 (TACTIC-R): a randomised, parallel-arm, open-label, phase 4 trial

2022

Affiliated Publications

• Association between hypertensive disorders of pregnancy and later risk of cardiovascular outcomes
• Early phase clinical trials extension to guidelines for the content of statistical analysis plans
• Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19
• Establishment of a validated central reading system for ileocolonoscopy in an academic setting
• How COVID-19 changed clinical research strategies: a global survey
• IDEAL-D Framework for Device Innovation: A Consensus Statement on the Preclinical Stage
• Initiation of Dialysis Is Associated With Impaired Cardiovascular Functional Capacity
• Myocardial Cytoskeletal Adaptations in Advanced Kidney Disease
• Niclosamide - a promising treatment for COVID-19
• The MITRE trial protocol: a study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapy
• Visualising harms in publications of randomised controlled trials: consensus and recommendations
• Predicting outcomes for Crohn's disease using a molecular biomarker: profile trial
• Effects of Exercise and Sleep Deprivation on Reaction Severity During Oral Peanut Challenge: A Randomized Controlled Trial
• Low-dose interleukin 2 for the reduction of vascular inflammation in acute coronary syndromes (IVORY): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase II clinical trial

LUCID

• Residual ctDNA after treatment predicts early relapse in patients with early-stage non-small cell lung cancer

TACTIC-E

• Niclosamide—A promising treatment for COVID-19

TAPS01

• A Feasibility Study of the Therapeutic Response and Durability of Short-term Androgen-targeted Therapy in Early Prostate Cancer Managed with Surveillance: The Therapeutics in Active Prostate Surveillance (TAPS01) Study.

2021

Affiliated Publications

• Age-Related Heterogeneity in Neutralising Antibody Responses to SARS-CoV-2 Following BNT162b2 Vaccination
• Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2
• A meta-analysis comparing the diagnostic performance of abbreviated MRI and a full diagnostic protocol in breast cancer
• Ambulatory blood pressure adaptations to high-intensity interval training: a randomized controlled study
• An Evaluation of Commonly Used Surrogate Baseline Creatinine Values to Classify AKI During Acute Infection
• An international survey of clinicians regarding their management of venous thromboembolism following the initial 3–6 months of anticoagulation
• Assessing the efficacy, safety and utility of closed-loop insulin delivery compared with sensor-augmented pump therapy in very young children with type 1 diabetes (KidsAP02 study): an open-label, multicentre, multinational, randomised cross-over study protocol
• ctDNA detection by personalised assays in early-stage NSCLC
• Economic Evaluation of Transperineal versus Transrectal Devices for Local Anaesthetic Prostate Biopsies
• Effects of Spironolactone and Chlorthalidone on Cardiovascular Structure and Function in Chronic Kidney Disease
• Establishing a Core Outcome Set for Autosomal Dominant Polycystic Kidney Disease: Report of the Standardized Outcomes in Nephrology–Polycystic Kidney Disease (SONG-PKD) Consensus Workshop
• Hyperglycaemia in the Newborn Infant. Physiology Verses Pathology
• IDEAL-D Framework for Device Innovation: A Consensus Statement on the Preclinical Stage
• Influence of Antiplatelet and Anticoagulant Drug Use on Outcomes after Chronic Subdural Hematoma Drainage
• Investigating the Lowest Threshold of Vascular Benefits from LDL Cholesterol Lowering with a PCSK9 mAb Inhibitor (Alirocumab) in Patients with Stable Cardiovascular Disease (INTENSITY-HIGH): protocol and study rationale for a randomised, open label, parallel group, mechanistic study
• Monitoring advances including consent: learning from COVID-19 trials and other trials running in UKCRC registered clinical trials units during the pandemic
• Per-Treatment Post Hoc Analysis of Clinical Trial Outcomes With Tolvaptan in ADPKD
• SARS-CoV-2 evolution during treatment of chronic infection
• Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
• The International Society of Nephrology Advancing Clinical Trials (ISN-ACT) Network: current activities and future goals
• Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn's disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource
• Quantitative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD

CCMR One

• Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study

ERICA

• Short physical performance battery as a practical tool to assess mortality risk in chronic obstructive pulmonary disease

HYPAZ

• Mechanisms Underlying Vascular Endothelial Growth Factor Receptor Inhibition-Induced Hypertension: The HYPAZ Trial

LILACS

• Innate Lymphoid Cells Promote Recovery of Ventricular Function After Myocardial Infarction

REACT

• Cost-effectiveness of real time continuous glucose monitoring to target glucose control in preterm infants

• Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial

TACTIC-E

• Endothelin antagonism and sodium glucose Co-transporter 2 inhibition. A potential combination therapeutic strategy for COVID-19

TACTIC-R

• Baricitinib set to join the Covid-19 therapeutic arsenal?

UK P3BEP

• P3BEP (ANZUP 1302): An international randomized phase III trial of accelerated versus standard BEP chemotherapy for male and female adults and children with intermediate and poor-risk metastatic germ cell tumors (GCTs).

2020

Affiliated Publication

• Advances in PET to assess pulmonary inflammation: A systematic review
• A meta-analysis comparing the diagnostic performance of abbreviated MRI and a full diagnostic protocol in breast cancer
• A multicentre, randomised controlled trial to compare the clinical and cost-effectiveness of Lee Silverman Voice Treatment versus standard NHS Speech and Language Therapy versus control in Parkinson’s disease: a study protocol for a randomised controlled trial
• Assessing the role of ketogenic dietary therapy in ring chromosome 20 syndrome: A patient-led approach
• Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy
• A quantitative analysis of the spatial and temporal evolution patterns of the bluetongue virus outbreak in the island of Lesvos, Greece, in 2014
• Cardiovascular Functional Reserve Before and After Kidney Transplant
• Combined Point-of-Care Nucleic Acid and Antibody Testing for SARS-CoV-2 following Emergence of D614G Spike Variant
• ctDNA monitoring using patient-specific sequencing and integration of variant reads
• Discussion and documentation of future care: a before-and-after study examining the impact of an alternative approach to recording treatment decisions on advance care planning in an acute hospital
• Drains result in greater reduction of subdural width and midline shift in burr hole evacuation of chronic subdural haematoma
• Effect of kidney donation on bone mineral metabolism
• Geospatial and Clinical Factors Associated with Frequent Emergency Department Use at a Washington DC Safety Net Hospital
• Impaired arterial vitamin D signaling occurs in the development of vascular calcification
• International consensus definitions of clinical trial outcomes for kidney failure: 2020
• Left atrial mechanics and aortic stiffness following high intensity interval training: a randomised controlled study
• Legal and ethical framework for global health information and biospecimen exchange - an international perspective
• OP0058-PARE MY SJÖGREN’S DIARY: AN ONLINE PATIENT PORTAL FOR PATIENT LED SJÖGREN’S SYNDROME RESEARCH
• Optimal Timing of External Ventricular Drainage after Severe Traumatic Brain Injury: A Systematic Review
• SAT-105 ALLOPURINOL FOR CVD IN CKD (AVOID-CKD): A DOUBLE BLIND, RANDOMIZED CONTROLLED TRIAL: DESIGN AND METHODS
• Systematic review of current randomised control trials in chronic subdural haematoma and proposal for an international collaborative approach
• Thiopurine monotherapy is effective in ulcerative colitis but significantly less so in Crohn’s disease: long-term outcomes for 11 928 patients in the UK inflammatory bowel disease bioresource

 AdDIT

• Medication Adherence During Adjunct Therapy With Statins and ACE Inhibitors in Adolescents With Type 1 Diabetes
• Vascular Effects of ACE (Angiotensin-Converting Enzyme) Inhibitors and Statins in Adolescents With Type 1 Diabetes

AZA-PD

• Azathioprine immunosuppression and disease modification in Parkinson's disease (AZA-PD): a randomised double-blind placebo-controlled phase II trial protocol

CamPROBE

• Multicentre clinical evaluation of the safety and performance of a simple transperineal access system for prostate biopsies for suspected prostate cancer: The CAMbridge PROstate Biopsy DevicE (CamPROBE) study

CLOuD

• Assessing the effect of closed-loop insulin delivery from onset of type 1 diabetes in youth on residual beta-cell function compared to standard insulin therapy (CLOuD study): a randomised parallel study protocol
• Health professionals' views about who would benefit from using a closed-loop system: a qualitative study
• What Training, Support, and Resourcing Do Health Professionals Need to Support People Using a Closed-Loop System? A Qualitative Interview Study with Health Professionals Involved in the Closed Loop from Onset in Type 1 Diabetes (CLOuD) Trial

Dex-CSDH

• Trial of Dexamethasone for Chronic Subdural Hematoma

DRINK

• High water vs. ad libitum water intake for autosomal dominant polycystic kidney disease: a randomized controlled feasibility trial

EARNEST

• Changes in Blood Pressure and Arterial Hemodynamics following Living Kidney Donation

ERICA

• Cardiovascular risk prediction using physical performance measures in COPD: results from a multicentre observational study

• Risk assessment for hospital admission in patients with COPD; a multi-centre UK prospective observational study

PERSEPHONE

• Six versus 12 months' adjuvant trastuzumab in patients with HER2-positive early breast cancer: the PERSEPHONE non-inferiority RCT

PROLIFIC

• ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers: A structured summary of a study protocol for a randomised controlled trial
• Correction to: ChemoPROphyLaxIs with hydroxychloroquine For covId-19 infeCtious disease (PROLIFIC) to prevent covid-19 infection in frontline healthcare workers: A structured summary of a study protocol for a randomised controlled trial

RITAZAREM

• Rituximab as therapy to induce remission after relapse in ANCA-associated vasculitis

SIEGE

• Scheduling nab-paclitaxel combined with gemcitabine as first-line treatment for metastatic pancreatic adenocarcinoma

TACTIC-E

• muLTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19-Experimental drugs and mechanisms (TACTIC-E): A structured summary of a study protocol for a randomized controlled trial

TACTIC-R

• Repurposed immunomodulatory drugs for Covid-19 in pre-ICu patients - mulTi-Arm Therapeutic study in pre-ICu patients admitted with Covid-19 – Repurposed Drugs (TACTIC-R): A structured summary of a study protocol for a randomised controlled trial

2019

Affiliated Publications

• Academic neurosurgery in the UK: present and future directions
• Anatomical change during radiotherapy for head and neck cancer, and its effect on delivered dose to the spinal cord
• A randomised, double-blind, placebo-controlled crossover trial of the influence of the HCN channel blocker ivabradine in a healthy volunteer pain model: an enriched population trial
• A zero coronary artery calcium score in patients with stable chest pain is associated with a good prognosis, despite risk of non-calcified plaques
• Contemporary statistical inference for infectious disease models using Stan
• Does Drain Position and Duration Influence Outcomes in Patients Undergoing Burr-Hole Evacuation of Chronic Subdural Hematoma? Lessons from a UK Multicenter Prospective Cohort Study
• Elucidating fitness components of the invasive dermestid beetle Trogoderma granarium combining deterministic and stochastic demography
• Investigating the lowest threshold of vascular benefits from LDL cholesterol lowering with a PCSK9 mAb inhibitor (alirocumab) in healthy volunteers - a mechanistic physiological study (INTENSITY-LOW): protocol and study rationale
• How to design a dose-finding study using the continual reassessment method
• Hyperphosphataemia in 2019: have we made progress?
• Mycophenolate mofetil versus cyclophosphamide for remission induction in ANCA-associated vasculitis: a randomised, non-inferiority trial
• Non-invasive measurements of arterial function: What? When? Why should we use them?
• No Surgical Innovation Without Evaluation: Evolution and Further Development of the IDEAL Framework and Recommendations
• Outcomes following surgery in subgroups of comatose and very elderly patients with chronic subdural hematoma
• Pharmacological management of post-traumatic seizures in adults: current practice patterns in the UK and the Republic of Ireland
• Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA2 five-stage study, including a workshop
• Quality of stepped-wedge trial reporting can be reliably assessed using an updated CONSORT: crowd-sourcing systematic review
• Quantifying normal human brain metabolism using hyperpolarized [1–¹³C]pyruvate and magnetic resonance imaging
• Targeting glucose control in preterm infants: pilot studies of continuous glucose monitoring
• Theory of general balance applied to step wedge designs
• Trajectories of Haemoglobin and incident stroke risk: a longitudinal cohort study
• Vitamin D and Atherosclerotic Cardiovascular Disease

 CAM-THY

• Keratinocyte growth factor impairs human thymic recovery from lymphopenia

DEX-CSDH

• Correction to: Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial

• Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma: report of the internal pilot phase
• Statistical analysis plan for the Dex-CSDH trial: a randomised, double-blind, placebo-controlled trial of a 2-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematoma

IASO

• Trial summary and protocol for a phase II randomised placebo-controlled double-blinded trial of Interleukin 1 blockade in Acute Severe Colitis: the IASO trial

KFORT

• Knee Fix or Replace Trial (KFORT): a randomized controlled feasibility study

PERSEPHONE

• 6 versus 12 months of adjuvant trastuzumab for HER2-positive early breast cancer (PERSEPHONE): 4-year disease-free survival results of a randomised phase 3 non-inferiority trial

SINAPPS2

• Intravenous immunoglobulin and rituximab versus placebo treatment of antibody-associated psychosis: study protocol of a randomised phase IIa double-blinded placebo-controlled trial (SINAPPS2)

TRACE

• Effect of sleep deprivation and exercise on reaction threshold in adults with peanut allergy: A randomized controlled study

2018

Affiliated Publications

• Brain tumor research in the United Kingdom: current perspective and future challenges. A strategy document from the NCRI Brain Tumor CSG
• Cost-Effectiveness and Value of Information Analysis of Brief Interventions to Promote Physical Activity in Primary Care
• DELTA² guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial
• Germline variation at 8q24 and prostate cancer risk in men of European ancestry
• Inverting the patient involvement paradigm: defining patient led research
• Outcomes following surgery in subgroups of comatose and very elderly patients with chronic subdural hematoma
• The British Neurosurgical Trainee Research Collaborative: Five years on
• The Rockwood geriatric clinical frailty scale is a more discriminatory tool for assessing older cancer patients compared with standard oncology performance status scales
• Using a retention in care protocol to promote positive health and systems related outcomes

 AdDIT

• Renal and Cardiovascular Risk According to Tertiles of Urinary Albumin-to-Creatinine Ratio: The Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial (AdDIT)

AIM-HY INFORM

• A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program—AIM-HY INFORM trial

Dex-CSDH

• Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial

DILfrequency

• The DILfrequency study is an adaptive trial to identify optimal IL-2 dosing in patients with type 1 diabetes

DRINK

• Randomised controlled trial of high versus ad libitum water intake in patients with autosomal dominant polycystic kidney disease: rationale and design of the DRINK feasibility trial

ERICA

• Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study
• Surrogate Markers of Cardiovascular Risk and Chronic Obstructive Pulmonary Disease

EVOLUTION

• The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled

• Vascular inflammation and aortic stiffness: potential mechanisms of increased vascular risk in chronic obstructive pulmonary disease

GALA-BIDD

• Local alkylating chemotherapy applied immediately after 5-ALA guided resection of glioblastoma does not provide additional benefit

LILACS

• Low-dose interleukin-2 in patients with stable ischaemic heart disease and acute coronary syndromes (LILACS): protocol and study rationale for a randomised, double-blind, placebo-controlled, phase I/II clinical trial

PROFILE

• PRedicting Outcomes For Crohn’s dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial

PT-1

• Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features

REACT

• Protocol of a randomised controlled trial of real-time continuous glucose monitoring in neonatal intensive care ‘REACT’

UK P3BEP

• Protocol for the P3BEP trial (ANZUP 1302): an international randomised phase 3 trial of accelerated versus standard BEP chemotherapy for adult and paediatric male and female patients with intermediate and poor-risk metastatic germ cell tumours

VoxTox

• Identifying risk factors for L’Hermitte’s sign after IMRT for head and neck cancer

2017

Affiliated Publications

• Analysis of heterogeneity in T₂-weighted MR images can differentiate pseudoprogression from progression in glioblastoma

• A randomized, multicenter, open-label, blinded end point trial comparing the effects of spironolactone to chlorthalidone on left ventricular mass in patients with early-stage chronic kidney disease: Rationale and design of the SPIRO-CKD trial

• Discussion and documentation of future care: a before-and-after study examining the impact of an alternative approach to recording treatment decisions on advance care planning in an acute hospital
• Does Reader Performance with Digital Breast Tomosynthesis Vary according to Experience with Two-dimensional Mammography?
• Improving the External Validity of Clinical Trials in Dialysis Populations
• Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers
• Meta-analysis of the prevalence of renal cancer detected by abdominal ultrasonography

• Negative anti-neutrophil cytoplasm antibody at switch to maintenance therapy is associated with a reduced risk of relapse

• Neonatal and adult recent thymic emigrants produce IL-8 and express complement receptors CR1 and CR2
• rpsftm: An R Package for Rank Preserving Structural Failure Time Models

• The INVEST project: investigating the use of evidence synthesis in the design and analysis of clinical trials

• Vitamin D and Its Role in CKD and CAD: A Novel Therapeutic Target

AdDIT

• ACE Inhibitors and Statins in Adolescents with Type 1 Diabetes
• Banting Memorial Lecture 2016 Reducing lifetime risk of complications in adolescents with Type 1 diabetes

ARTemis

• Central pathology review with two-stage quality assurance for pathological response after neoadjuvant chemotherapy in the ARTemis Trial
• Disease-free and overall survival at 3.5 years for neoadjuvant bevacizumab added to docetaxel followed by fluorouracil, epirubicin and cyclophosphamide, for women with HER2 negative early breast cancer: ARTemis Trial

BUBBLE

• Microbubble detection and ultrasound-guided vacuum-assisted biopsy of axillary lymph nodes in patients with breast cancer

DILT1D

• Capturing the systemic immune signature of a norovirus infection: an n-of-1 case study within a clinical trial

• Human IL-6R^hiTIGIT⁻ CD4⁺ CD127^lowCD25⁺ T cells display potent in vitro suppressive capacity and a distinct Th17 profile

DRINK

• Patient Survey of current water Intake practices in autosomal dominant Polycystic kidney disease: the SIPs survey

ERICA

• Longitudinal follow-up of quadriceps strength and function in a COPD cohort after 3 years

EVOLUTION

• Quantitative analysis of dynamic ¹⁸F-FDG PET/CT for measurement of lung inflammation

RESCUE-ASDH

• Survival Trends After Surgery for Acute Subdural Hematoma in Adults Over a 20-year Period

RITAZAREM

• Rituximab versus azathioprine as therapy for maintenance of remission for anti-neutrophil cytoplasm antibody-associated vasculitis (RITAZAREM): study protocol for a randomized controlled trial

STASH

• What Factors Determine Treatment Outcome in Aneurysmal Subarachnoid Hemorrhage in the Modern Era? A Post Hoc STASH Analysis

VoxTox

• Applying physical science techniques and CERN technology to an unsolved problem in radiation treatment for cancer: the multidisciplinary ‘VoxTox’ research programme
• Delivered dose can be a better predictor of rectal toxicity than planned dose in prostate radiotherapy